Cell surface localization and release of the candidate tumor suppressor Ecrg4 from polymorphonuclear cells and monocytes activate macrophages

We identified fresh human leukocytes as an abundant source of the candidate epithelial tumor suppressor gene, Ecrg4, an epigenetically regulated gene, which unlike other tumor suppressor genes, encodes an orphan-secreted, ligand-like protein. In human cell lines, Ecrg4 gene expression was low, Ecrg4...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Baird, Andrew, Coimbra, Raul, Dang, Xitong, Lopez, Nicole, Lee, Jisook, Krzyzaniak, Michael, Winfield, Robert, Potenza, Bruce, Eliceiri, Brian P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2012
Schlagworte:
Inflammation, Extracellular Mediators, & Effector Molecules
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336773/
https://ncbi.nlm.nih.gov/pubmed/22396620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1011503
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