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Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53
The serine/threonine protein kinase Aurora A is known to interact with and phosphorylate tumor suppressor p53 at Serine 215 (S215), inhibiting the transcriptional activity of p53. We show that Aurora A positively regulates human p53 protein levels and, using isogenic p53 wild-type and p53-null color...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335940/ https://ncbi.nlm.nih.gov/pubmed/22157150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.12.18141 |
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