Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1

HIV-1 is internalized into mature dendritic cells (mDCs) via an as yet undefined mechanism with subsequent transfer of stored, infectious virus to CD4(+) T lymphocytes. Thus, HIV-1 subverts a DC antigen capture mechanism to promote viral spread. Here, we show that gangliosides in the HIV-1 membrane...

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Main Authors: Izquierdo-Useros, Nuria, Lorizate, Maier, Contreras, F.-Xabier, Rodriguez-Plata, Maria T., Glass, Bärbel, Erkizia, Itziar, Prado, Julia G., Casas, Josefina, Fabriàs, Gemma, Kräusslich, Hans-Georg, Martinez-Picado, Javier
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335875/
https://ncbi.nlm.nih.gov/pubmed/22545022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001315
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