Novel Regulatory Mechanisms for Generation of the Soluble Leptin Receptor: Implications for Leptin Action

BACKGROUND: The adipokine leptin realizes signal transduction via four different membrane-anchored leptin receptor (Ob-R) isoforms in humans. However, the amount of functionally active Ob-R is affected by constitutive shedding of the extracellular domain via a so far unknown mechanism. The product o...

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Detalhes bibliográficos
Main Authors: Schaab, Michael, Kausch, Henriette, Klammt, Juergen, Nowicki, Marcin, Anderegg, Ulf, Gebhardt, Rolf, Rose-John, Stefan, Scheller, Juergen, Thiery, Joachim, Kratzsch, Juergen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335825/
https://ncbi.nlm.nih.gov/pubmed/22545089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034787
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