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The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation

The β-globin locus control region (LCR) is necessary for high-level β-globin gene transcription and differentiation-dependent relocation of the β-globin locus from the nuclear periphery to the central nucleoplasm and to foci of hyperphosphorylated Pol II “transcription factories” (TFys). To determin...

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Main Authors: Bender, M. A., Ragoczy, Tobias, Lee, Jongjoo, Byron, Rachel, Telling, Agnes, Dean, Ann, Groudine, Mark
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335386/
https://ncbi.nlm.nih.gov/pubmed/22378846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-380485
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