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The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer.

Like Cyclosporin A (CsA), the macrolide FK 506 is a potent immunosuppressive that inhibits early steps of T cell activation, including the synthesis of Interleukin 2 (II-2) and numerous other lymphokines. The block of II-2 synthesis occurs at the transcriptional level. At concentrations that block T...

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Hlavní autoři: Brabletz, T, Pietrowski, I, Serfling, E
Médium: Artigo
Jazyk:Inglês
Vydáno: 1991
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC333534/
https://ncbi.nlm.nih.gov/pubmed/1707162
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