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Vimentin and PSF Act in Concert to Regulate IbeA+ E. coli K1 Induced Activation and Nuclear Translocation of NF-κB in Human Brain Endothelial Cells

BACKGROUND: IbeA-induced NF-κB signaling through its primary receptor vimentin as well as its co-receptor PSF is required for meningitic E. coli K1 penetration and leukocyte transmigration across the blood-brain barrier (BBB), which are the hallmarks of bacterial meningitis. However, it is unknown h...

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書目詳細資料
Main Authors: Chi, Feng, Bo, Tao, Wu, Chun-Hua, Jong, Ambrose, Huang, Sheng-He
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334993/
https://ncbi.nlm.nih.gov/pubmed/22536447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035862
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