High-Order SNP Combinations Associated with Complex Diseases: Efficient Discovery, Statistical Power and Functional Interactions

There has been increased interest in discovering combinations of single-nucleotide polymorphisms (SNPs) that are strongly associated with a phenotype even if each SNP has little individual effect. Efficient approaches have been proposed for searching two-locus combinations from genome-wide datasets....

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Hlavní autoři: Fang, Gang, Haznadar, Majda, Wang, Wen, Yu, Haoyu, Steinbach, Michael, Church, Timothy R., Oetting, William S., Van Ness, Brian, Kumar, Vipin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334940/
https://ncbi.nlm.nih.gov/pubmed/22536319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033531
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