Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab

BACKGROUND: The epidermal growth factor receptor (EGFR) is a validated therapeutic target in non-small cell lung cancer (NSCLC). However, current single agent receptor targeting does not achieve a maximal therapeutic effect, and some mutations confer resistance to current available agents. In the cu...

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Detalhes bibliográficos
Main Authors: Chen, Gang, Kronenberger, Peter, Teugels, Erik, Umelo, Ijeoma Adaku, De Grève, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334713/
https://ncbi.nlm.nih.gov/pubmed/22436374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-10-28
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