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Abnormalities of the Duo/Rac-1/PAK1 Pathway Drive Myosin Light Chain Phosphorylation in Frontal Cortex in Schizophrenia
BACKGROUND: Recent studies on GTPases have suggested that reduced Duo and Cdc42 transcript expression is involved in dendritic spine loss in schizophrenia. In murine models, Duo and Cdc42 phosphorylate PAK1, which modifies the activity of regulatory myosin light chain (MLC) and cofilin by altering t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3334466/ https://ncbi.nlm.nih.gov/pubmed/22458949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.02.006 |
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