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Normalized Affymetrix expression data are biased by G-quadruplex formation
Probes with runs of four or more guanines (G-stacks) in their sequences can exhibit a level of hybridization that is unrelated to the expression levels of the mRNA that they are intended to measure. This is most likely caused by the formation of G-quadruplexes, where inter-probe guanines form Hoogst...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3333884/ https://ncbi.nlm.nih.gov/pubmed/22199258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1230 |
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