Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine. Tet1 is robustly expressed in mouse embryonic stem cells (mESC...

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Bibliographic Details
Main Authors: Freudenberg, Johannes M., Ghosh, Swati, Lackford, Brad L., Yellaboina, Sailu, Zheng, Xiaofeng, Li, Ruifang, Cuddapah, Suresh, Wade, Paul A., Hu, Guang, Jothi, Raja
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3333871/
https://ncbi.nlm.nih.gov/pubmed/22210859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1253
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