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Structure of the S. aureus PI-specific phospholipase C reveals modulation of active site access by a titratable π-cation latched loop

Staphylococcus aureus secretes a phosphatidylinositol-specific phospholipase C (PIPLC) as a virulence factor that is unusual in exhibiting higher activity at acidic pH values than other enzymes in this class. We have determined the crystal structure of this enzyme at pH 4.6 and pH 7.5. Under slightl...

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Hlavní autoři: Goldstein, Rebecca, Cheng, Jiongjia, Stec, Boguslaw, Roberts, Mary F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332126/
https://ncbi.nlm.nih.gov/pubmed/22390775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300057q
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