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Structure of the S. aureus PI-specific phospholipase C reveals modulation of active site access by a titratable π-cation latched loop
Staphylococcus aureus secretes a phosphatidylinositol-specific phospholipase C (PIPLC) as a virulence factor that is unusual in exhibiting higher activity at acidic pH values than other enzymes in this class. We have determined the crystal structure of this enzyme at pH 4.6 and pH 7.5. Under slightl...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3332126/ https://ncbi.nlm.nih.gov/pubmed/22390775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300057q |
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