Lestaurtinib Inhibits Histone Phosphorylation and Androgen-Dependent Gene Expression in Prostate Cancer Cells

BACKGROUND: Epigenetics is defined as heritable changes in gene expression that are not based on changes in the DNA sequence. Posttranslational modification of histone proteins is a major mechanism of epigenetic regulation. The kinase PRK1 (protein kinase C related kinase 1, also known as PKN1) phos...

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Autors principals: Köhler, Jens, Erlenkamp, German, Eberlin, Adrien, Rumpf, Tobias, Slynko, Inna, Metzger, Eric, Schüle, Roland, Sippl, Wolfgang, Jung, Manfred
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332061/
https://ncbi.nlm.nih.gov/pubmed/22532837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034973
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