Disruption of a GATA4/Ankrd1 Signaling Axis in Cardiomyocytes Leads to Sarcomere Disarray: Implications for Anthracycline Cardiomyopathy

Doxorubicin (Adriamycin) is an effective anti-cancer drug, but its clinical usage is limited by a dose-dependent cardiotoxicity characterized by widespread sarcomere disarray and loss of myofilaments. Cardiac ankyrin repeat protein (CARP, ANKRD1) is a transcriptional regulatory protein that is extre...

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Bibliographic Details
Main Authors: Chen, Billy, Zhong, Lin, Roush, Sarah F., Pentassuglia, Laura, Peng, Xuyang, Samaras, Susan, Davidson, Jeffrey M., Sawyer, Douglas B., Lim, Chee Chew
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332030/
https://ncbi.nlm.nih.gov/pubmed/22532871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035743
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