Primary Transgenic Bovine Cells and Their Rejuvenated Cloned Equivalents Show Transgene-Specific Epigenetic Differences

Cell-mediated transgenesis, based on somatic cell nuclear transfer (SCNT), provides the opportunity to shape the genetic make-up of cattle. Bovine primary fetal fibroblasts, commonly used cells for SCNT, have a limited lifespan, and complex genetic modifications that require sequential transfections...

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Bibliografiska uppgifter
Huvudupphovsmän: Alonso-González, Lucia, Couldrey, Christine, Meinhardt, Marcus W., Cole, Sally A., Wells, David N., Laible, Götz
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332029/
https://ncbi.nlm.nih.gov/pubmed/22532863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035619
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