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Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibition Improves Coronary Arteriole Function in Type 2 Diabetes

Type 2 diabetes (T2D) is associated with microvascular dysfunction. We hypothesized that increased Poly - (ADP-ribose) polymerase-1 (PARP-1) activity contributes to microvascular dysfunction in T2D. T2D (db(-)/db(-)) and non-diabetic control (db(-)/db(+)) mice were treated with two different PARP-1...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Choi, Soo-Kyoung, Galán, Maria, Kassan, Modar, Partyka, Megan, Trebak, Mohamed, Matrougui, Khalid
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331962/
https://ncbi.nlm.nih.gov/pubmed/22454481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.111.190140
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