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Optogenetic stimulation of a hippocampal engram activates fear memory recall

A specific memory is thought to be encoded by a sparse population of neurons(1,2). These neurons can be tagged during learning for subsequent identification(3) and manipulation(4,5,6). Moreover, their ablation or inactivation results in reduced memory expression, suggesting their necessity in mnemon...

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Detalhes bibliográficos
Main Authors: Liu, Xu, Ramirez, Steve, Pang, Petti T., Puryear, Corey B., Govindarajan, Arvind, Deisseroth, Karl, Tonegawa, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331914/
https://ncbi.nlm.nih.gov/pubmed/22441246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11028
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