De novo synthesis of purine nucleotides in human peripheral blood leukocytes. Excessive activity of the pathway in hypoxanthine-guanine phosphoribosyltransferase deficiency.

Human peripheral blood leukocytes were studied for the presence and the regulatory properties of the pathway of de novo synthesis of purine nucleotides. The cells were found to incorporate the labeled precursors formate and glycine into purines. The rate of [14C]-formate incorporation was decreased...

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Udgivet i:J Clin Invest
Main Authors: Brosh, S, Boer, P, Kupfer, B, de Vries, A, Sperling, O
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1976
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC333182/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/956368/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI108471
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