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Caspase-1 and 3 Inhibiting Drimane Sesquiterpenoids from the Extremophilic Fungus, Penicillium solitum

Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes cas...

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Detalhes bibliográficos
Main Authors: Stierle, Donald B., Stierle, Andrea A., Girtsman, Teri, McIntyre, Kyle, Nichols, Jesse
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330828/
https://ncbi.nlm.nih.gov/pubmed/22276851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200528n
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