Cardiomyocyte overexpression of the α(1a)-adrenergic receptor in the rat phenocopies second but not first window preconditioning

We examined α(1A)-adrenergic receptor (AR) mediation of preconditioning in a novel α(1A)-AR cardiac transgenic (TG) rat model (α(1A)-TG). Compared with nontransgenic littermates (NTLs), in conscious α(1A)-TG rats, heart rate was reduced, contractility [left ventricle (LV) +dP/dt, ejection fraction,...

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Detalhes bibliográficos
Main Authors: Zhao, Xin, Park, Jiyeon, Ho, David, Gao, Shumin, Yan, Lin, Ge, Hui, Iismaa, Siiri, Lin, Lin, Tian, Bin, Vatner, Dorothy E., Graham, Robert M., Vatner, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Cardiovascular Neurohormonal Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330800/
https://ncbi.nlm.nih.gov/pubmed/22307672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01072.2011
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