Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue

Illumination of vertebrate rod photoreceptors leads to a decrease in the cytoplasmic cGMP concentration and closure of cyclic nucleotide-gated (CNG) channels. Except for Ca(2+), which plays a negative feedback role in adaptation, and 11-cis-retinal, supplied by the retinal pigment epithelium, all of...

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Bibliographic Details
Main Authors: Savchenko, Alexei, Kraft, Timothy W., Molokanova, Elena, Kramer, Richard H.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC33307/
https://ncbi.nlm.nih.gov/pubmed/11320223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101524998
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