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Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
BACKGROUND: The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and α7* nicotinic receptors. METHODS: The...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3329991/ https://ncbi.nlm.nih.gov/pubmed/20729465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbq086 |
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