The Characterization of the Caenorhabditis elegans Mitochondrial Thioredoxin System Uncovers an Unexpected Protective Role of Thioredoxin Reductase 2 in β-Amyloid Peptide Toxicity

Aim: Functional in vivo studies on the mitochondrial thioredoxin system are hampered by the embryonic or larval lethal phenotypes displayed by murine or Drosophila knock-out models. Thus, the access to alternative metazoan knock-out models for the mitochondrial thioredoxin system is of critical impo...

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Détails bibliographiques
Auteurs principaux: Cacho-Valadez, Briseida, Muñoz-Lobato, Fernando, Pedrajas, José Rafael, Cabello, Juan, Fierro-González, Juan Carlos, Navas, Plácido, Swoboda, Peter, Link, Chris D., Miranda-Vizuete, Antonio
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2012
Sujets:
Original Research Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329951/
https://ncbi.nlm.nih.gov/pubmed/22220943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4265
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