USE OF THE γ-H2AX ASSAY TO MONITOR DNA DAMAGE AND REPAIR IN TRANSLATIONAL CANCER RESEARCH

Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis for a sensitive assay of DNA damage in human biopsies. The review focuses on the application of γ-H2AX-based methods to translational studies to monitor the clinical response to DNA targeted therapies such as som...

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Main Authors: Ivashkevich, Alesia, Redon, Christophe E., Nakamura, Asako J., Martin, Roger F., Martin, Olga A.
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329565/
https://ncbi.nlm.nih.gov/pubmed/22198208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.12.025
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