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Ethanol-Mediated Regulation of Cytochrome P450 2A6 Expression in Monocytes: Role of Oxidative Stress-Mediated PKC/MEK/Nrf2 Pathway

Cytochrome P450 2A6 (CYP2A6) is known to metabolize nicotine, the major constituent of tobacco, leading to the production of toxic metabolites and induction of oxidative stress that result in liver damage and lung cancer. Recently, we have shown that CYP2A6 is induced by ethanol and metabolizes nico...

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Bibliographic Details
Main Authors: Jin, Mengyao, Kumar, Anil, Kumar, Santosh
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329463/
https://ncbi.nlm.nih.gov/pubmed/22530035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035505
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