PDGF enhances store-operated Ca(2+) entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells

Platelet-derived growth factor (PDGF) and its receptor are known to be substantially elevated in lung tissues and pulmonary arterial smooth muscle cells (PASMC) isolated from patients and animals with pulmonary arterial hypertension. PDGF has been shown to phosphorylate and activate Akt and mammalia...

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Bibliographic Details
Main Authors: Ogawa, Aiko, Firth, Amy L., Smith, Kimberly A., Maliakal, Mary V., Yuan, Jason X.-J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Membrane Transporters, Ion Channels and Pumps
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328839/
https://ncbi.nlm.nih.gov/pubmed/22031597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00337.2011
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