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Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A(2A) adenosine receptor in rats

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin induce gastric mucosal lesions in part by the activation of inflammatory cells and the production of proinflammatory cytokines. The activation of adenosine A(2A) receptors inhibits inflammation by increasing cyclic AMP in...

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Detalhes bibliográficos
Main Authors: Koizumi, Shigeto, Odashima, Masaru, Otaka, Michiro, Jin, Mario, Linden, Joel, Watanabe, Sumio, Ohnishi, Hirohide
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328190/
https://ncbi.nlm.nih.gov/pubmed/19333545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-009-0028-8
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