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Destabilization of the Outer and Inner Mitochondrial Membranes by Core and Linker Histones

BACKGROUND: Extensive DNA damage leads to apoptosis. Histones play a central role in DNA damage sensing and may mediate signals of genotoxic damage to cytosolic effectors including mitochondria. METHODOLOGY/PRINCIPAL FINDINGS: We have investigated the effects of histones on mitochondrial function an...

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Autors principals: Cascone, Annunziata, Bruelle, Celine, Lindholm, Dan, Bernardi, Paolo, Eriksson, Ove
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327664/
https://ncbi.nlm.nih.gov/pubmed/22523586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035357
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