Wird geladen...

Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase

Gaucher disease is a lysosomal storage disorder caused by a defect in the degradation of glucosylceramide catalyzed by the lysosomal enzyme β-glucocerebrosidase (GBA). GBA reaches lysosomes via association with its receptor, lysosomal integral membrane protein type 2 (LIMP-2). We found that distinct...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Jović, Marko, Kean, Michelle J., Szentpetery, Zsofia, Polevoy, Gordon, Gingras, Anne-Claude, Brill, Julie A., Balla, Tamas
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327330/
https://ncbi.nlm.nih.gov/pubmed/22337770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-06-0553
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!