Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells

BACKGROUND: In addition to the mutational status of KRAS, the epidermal growth factor receptor (EGFR) ligands amphiregulin (AREG) and epiregulin (EREG) might function as bona fide biomarkers of cetuximab (Ctx) sensitivity for most EGFR-driven carcinomas. METHODS: Lentivirus-delivered small hairpin R...

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Detalhes bibliográficos
Main Authors: Oliveras-Ferraros, C, Cufí, S, Queralt, B, Vazquez-Martin, A, Martin-Castillo, B, de Llorens, R, Bosch-Barrera, J, Brunet, J, Menendez, J A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326676/
https://ncbi.nlm.nih.gov/pubmed/22491422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.103
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