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Structure–Activity Relationships, Ligand Efficiency, and Lipophilic Efficiency Profiles of Benzophenone-Type Inhibitors of the Multidrug Transporter P-Glycoprotein
[Image: see text] The drug efflux pump P-glycoprotein (P-gp) has been shown to promote multidrug resistance (MDR) in tumors as well as to influence ADME properties of drug candidates. Here we synthesized and tested a series of benzophenone derivatives structurally analogous to propafenone-type inhib...
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| Главные авторы: | , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical
Society
2012
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326594/ https://ncbi.nlm.nih.gov/pubmed/22452412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201705f |
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