Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure

Retinoic acid decreases proteinuria and glomerulosclerosis in several animal models of kidney disease by protecting podocytes from injury. Our recent in vitro studies suggest that all-trans retinoic acid induces podocyte differentiation by activating the retinoic acid receptor-α (RARα)/cAMP/PKA/CREB...

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Main Authors: Zhong, Yifei, Wu, Yingwei, Liu, Ruijie, Deng, Yueyi, Mallipattu, Sandeep, Klotman, Paul, Chuang, Peter, He, John Cijiang
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326224/
https://ncbi.nlm.nih.gov/pubmed/22258322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2011.467
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