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A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding
We conducted a pharmacokinetic (PK) study of mitoxantrone (Novantrone®), a clinically well-established anticancer agent, in mice and developed a mechanism-based PBPK (physiologically based pharmacokinetic) model to describe its disposition. Mitoxantrone concentrations in plasma and six organs (lung,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326165/ https://ncbi.nlm.nih.gov/pubmed/22451016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9344-7 |
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