Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA)

The genes PRKACA and PRKACB encode the principal catalytic (C) subunits of protein kinase A (PKA) Cα and Cβ, respectively. Cα is expressed in all eukaryotic tissues examined and studies of Cα knockout mice demonstrate a crucial role for Cα in normal physiology. We have sequenced exon 2 through 10 of...

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Detalhes bibliográficos
Main Authors: Søberg, Kristoffer, Larsen, Anja C. V., Diskar, Mandy, Backe, Paul H., Bjørås, Magnar, Jahnsen, Tore, Laerdahl, Jon K., Rognes, Torbjørn, Herberg, Friedrich W., Skålhegg, Bjørn S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325940/
https://ncbi.nlm.nih.gov/pubmed/22514673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034838
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