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Tibial Loading Increases Osteogenic Gene Expression and Cortical Bone Volume in Mature and Middle-Aged Mice

There are conflicting data on whether age reduces the response of the skeleton to mechanical stimuli. We examined this question in female BALB/c mice of different ages, ranging from young to middle-aged (2, 4, 7, 12 months). We first assessed markers of bone turnover in control (non-loaded) mice. Se...

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Detalhes bibliográficos
Main Authors: Silva, Matthew J., Brodt, Michael D., Lynch, Michelle A., Stephens, Abby L., Wood, Daniel J., Civitelli, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325918/
https://ncbi.nlm.nih.gov/pubmed/22514696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034980
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