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Persistence or loss of preimposed methylation patterns and de novo methylation of foreign DNA integrated in transgenic mice.

In cultured mammalian cells, foreign DNA can be integrated into the host genome. Foreign DNA is frequently de novo methylated in specific patterns with successive cell generations. The sequence-specific methylation of promoter sequences in integrated foreign DNA is associated with the long-term inac...

詳細記述

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書誌詳細
主要な著者: Lettmann, C, Schmitz, B, Doerfler, W
フォーマット: Artigo
言語:Inglês
出版事項: 1991
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC332538/
https://ncbi.nlm.nih.gov/pubmed/1837354
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