Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network Study

OBJECTIVE: Fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPARα) agonist, reduces triglyceride (TG) concentrations by 25–60%. Given significant inter-individual variation in TG response, we investigated the association of PPARA rare variants with treatment response in the Genetics...

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Bibliografiset tiedot
Päätekijät: Irvin, Marguerite R, Zhang, Qunyuan, Kabagambe, Edmond K, Perry, Rodney T, Straka, Robert J., Tiwari, Hemant K, Borecki, Ingrid B, Shimmin, Lawrence C., Stuart, Colin, Zhong, Yu, Hixson, James E, Arnett, Donna K
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325369/
https://ncbi.nlm.nih.gov/pubmed/22336959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328351a486
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