A paradigm for local conformational control of function in the ribosome: binding of ribosomal protein S19 to Escherichia coli 16S rRNA in the presence of S7 is required for methylation of m2G966 and blocks methylation of m5C967 by their respective methyltransferases.

We have partially purified two 16S rRNA-specific methyltransferases, one of which forms m2G966 (m2G MT), while the other one makes m5C967 (m5C MT). The m2G MT uses unmethylated 30S subunits as a substrate, but not free unmethylated 16S rRNA, while the m5C MT functions reciprocally, using free rRNA b...

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Bibliographic Details
Main Authors: Weitzmann, C, Tumminia, S J, Boublik, M, Ofengand, J
Format: Artigo
Language:Inglês
Published: 1991
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC332521/
https://ncbi.nlm.nih.gov/pubmed/1766869
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