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LACK OF AQUAPORIN-4 WATER TRANSPORT INHIBITION BY ANTIEPILEPTICS AND ARYLSULFONAMIDES

Inhibitors of brain glial water channel aquaporin-4 (AQP4) are of potential clinical utility, as they are predicted to modulate brain edema, neuroexcitation and glial scarring. Recently, Huber et al. (Bioorgan. Med. Chem. 2007, 17:1270-3; 2008, in press) reported that a series of arylsulfomamides, a...

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Detalhes bibliográficos
Main Authors: Yang, Baoxue, Zhang, Hua, Verkman, A.S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325054/
https://ncbi.nlm.nih.gov/pubmed/18572411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.06.005
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