Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)

High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is released passively during cell injury and necrosis, and secreted actively by immune cells. HMGB1 contains three conserved redox-sensitive cysteine residues: C23 and C45 can form an intramo...

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Main Authors: Yang, Huan, Lundbäck, Peter, Ottosson, Lars, Erlandsson-Harris, Helena, Venereau, Emilie, Bianchi, Marco E, Al-Abed, Yousef, Andersson, Ulf, Tracey, Kevin J, Antoine, Daniel J
Format: Artigo
Language:Inglês
Published: ScholarOne 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324950/
https://ncbi.nlm.nih.gov/pubmed/22105604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00389
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