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Repetitive DNA and next-generation sequencing: computational challenges and solutions
Repetitive DNA sequences are abundant in a broad range of species, from bacteria to mammals, and they cover nearly half of the human genome. Repeats have always presented technical challenges for sequence alignment and assembly programs. Next-generation sequencing projects, with their short read len...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3324860/ https://ncbi.nlm.nih.gov/pubmed/22124482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3117 |
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