Anticancer β-hairpin peptides: membrane-induced folding triggers activity

Several cationic antimicrobial peptides (AMPs) have recently been shown to display anticancer activity via a mechanism that usually entails the disruption of cancer cell membranes. In this work, we designed an 18-residue anticancer peptide, SVS-1, whose mechanism of action is designed to take advant...

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Bibliografiske detaljer
Main Authors: Sinthuvanich, Chomdao, Veiga, Ana Salomé, Gupta, Kshitij, Gaspar, Diana, Blumenthal, Robert, Schneider, Joel P.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324662/
https://ncbi.nlm.nih.gov/pubmed/22413859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja210569f
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