Human γδ T lymphocytes induce robust NK cell–mediated antitumor cytotoxicity through CD137 engagement

Natural killer (NK) cells are innate effector lymphocytes that control the growth of major histocompatibility complex class I negative tumors. We show here that γδ T lymphocytes, expanded in vitro in the presence isopentenylpyrophosphate (IPP), induce NK cell–mediated killing of tumors that are usua...

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Bibliographic Details
Main Authors: Maniar, Amudhan, Zhang, Xiaoyu, Lin, Wei, Gastman, Brian R., Pauza, C. David, Strome, Scott E., Chapoval, Andrei I.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324253/
https://ncbi.nlm.nih.gov/pubmed/20519625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-234211
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