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Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca(2+) spike frequency

In the brains of patients with fetal Minamata disease (FMD), which is caused by exposure to methylmercury (MeHg) during development, many neurons are hypoplastic, ectopic, and disoriented, indicating disrupted migration, maturation, and growth. MeHg affects a myriad of signaling molecules, but littl...

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Main Authors: Fahrion, Jennifer K., Komuro, Yutaro, Li, Ying, Ohno, Nobuhiko, Littner, Yoav, Raoult, Emilie, Galas, Ludovic, Vaudry, David, Komuro, Hitoshi
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323999/
https://ncbi.nlm.nih.gov/pubmed/22411806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120747109
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