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Initiation factor 2, tRNA, and 50S subunits cooperatively stabilize mRNAs on the ribosome during initiation

Initiation factor 2 (IF2) is a key factor in initiation of bacterial protein synthesis. It recruits initiator tRNA to the small ribosomal subunit and facilitates joining of the large ribosomal subunit. Using reconstituted translation system of Escherichia coli and optical tweezers, we directly measu...

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Détails bibliographiques
Auteurs principaux: Masuda, Tomoaki, Petrov, Alexey N., Iizuka, Ryo, Funatsu, Takashi, Puglisi, Joseph D., Uemura, Sotaro
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323968/
https://ncbi.nlm.nih.gov/pubmed/22411833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118452109
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