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Engineering Proteins with Enhanced Mechanical Stability by Force Specific Sequence Motifs

Use of atomic force microscopy (AFM) has recently led to a better understanding of the molecular mechanisms of the unfolding process by mechanical forces; however, the rational design of novel proteins with specific mechanical strength remains challenging. We have approached this problem from a new...

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Hlavní autoři: Lu, Wenzhe, Negi, Surendra, Oberhauser, Andres F., Braun, Werner
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323705/
https://ncbi.nlm.nih.gov/pubmed/22274941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24027
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