STAT3 Regulates Monocyte TNF-Alpha Production in Systemic Inflammation Caused by Cardiac Surgery with Cardiopulmonary Bypass

BACKGROUND: Cardiopulmonary bypass (CPB) surgery initiates a controlled systemic inflammatory response characterized by a cytokine storm, monocytosis and transient monocyte activation. However, the responsiveness of monocytes to Toll-like receptor (TLR)-mediated activation decreases throughout the p...

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Main Authors: de Jong, Petrus R., Schadenberg, Alvin W. L., van den Broek, Theo, Beekman, Jeffrey M., van Wijk, Femke, Coffer, Paul J., Prakken, Berent J., Jansen, Nicolaas J. G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323636/
https://ncbi.nlm.nih.gov/pubmed/22506067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035070
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