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Versatility of Cooperative Transcriptional Activation: A Thermodynamical Modeling Analysis for Greater-Than-Additive and Less-Than-Additive Effects

We derive a statistical model of transcriptional activation using equilibrium thermodynamics of chemical reactions. We examine to what extent this statistical model predicts synergy effects of cooperative activation of gene expression. We determine parameter domains in which greater-than-additive an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Frank, Till D., Carmody, Aimée M., Kholodenko, Boris N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323628/
https://ncbi.nlm.nih.gov/pubmed/22506020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034439
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